ACE inhibitor became one of popular form of effective antihypertensive therapy. Fosinopril (Monopril(r)) is a new ACE inhibitor recently made available for the treatment of hpertension. To evailable for the treatment of Fosinopril, once daily
therapy
was done in 20 patients with essential hypertension. Patient's seated diastolic blood pressure response ot fosinopril treatment was normla 85%(16/120), responsive 10%92/20) and no response 10%(2/200. After 2 weeks of fosinopril therapy, the
average
percentage changes n systolic and diastolic BP were 9.3/9.%(10 mg), 7.0/8.1%(20 mg), 4.9/3.2%(20 mg), 1.3/0%(30 mg) and 1.3/2.0%(40 mg + thiazside).
Fosinopril was toterated. Only two patients withdrew because of adverse events possibly related to Fosinopril (hyperkalemia & cough).
In conclusion, treatment with Fosinopril generally was safe and well tolerated. Cnce-daily Fosinopril was an effective antihypertensive for 24 hours in some patients with essential hypertension and a clinical study of larger number of patients
will
be
needed.
|